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Animal and human studies with the mitochondria-targeted antioxidant MitoQ
Introducing antioxidants into the culture media effectively counteracts ROS levels []
Similar to the brain, it is also known that the spinal cord, especially SG neurons, is critical to pain pathways, and modulates nociceptive transmission via primary afferent A- and C-fibers (Yang et al., 1998
As Conrozier noted, despite the well-established link between obesity and OA, there have historically been no specific recommendations for the medical management of obese patients with OA beyond advising weight loss and regular physical activity in addition to usual care (Conrozier, 2020)
