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Edema Well-demarcated papules and nodules in affected area (may be pigmented) Most common in lower legs/ shins Shins Erythema Nodosum (pretibial area) Can affect feet, arms, elbows, face Thyroid Thyroid The thyroid gland is one of the largest endocrine glands in the human body

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This makes it critical for plan sponsors to clearly define when compounded GLP-1s are clinically appropriate and legally supportable, even in a post-shortage environment

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4 Unlike transketolase, PDH, KGDH, and BCKD enzymes which are located in the mitochondria, this enzyme is found in the peroxisomes of mammalian cells