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10.1161/ATVBAHA.119.313200 Arterioscler Thromb Vasc Biol

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This hormone-like action is the basis for both its approved medical use and its cosmetic effects

For example, altered levels of short-chain ACs, including C2 and C3, have been observed in coronary artery disease and diabetes [6, 55]

We have previously shown that, in the region surrounding the NPEY motif, 4 out of 16 residues differ between the IR and IGF1R (equivalent to Pro963, Ser968, Leu973, and Ser976 in the IR) and by systematic substitution of each of these residues showed that only replacement of leucine-973, the residue in the +1 position following the NPEY motif, with phenylalanine results in a shift from binding IRS-1 to binding Shc in a receptor pull-down assay (14)