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YoshikawaMPongpiriyadachaYKishiAKageuraTWangTMorikawaTet al
The targets of area postrema neuronal projections include the rostral ventrolateral medulla (RVLM), with the efferent projections from the RVLM innervating the sympathetic preganglionic neurons (183)
As a result, some people taking tirzepatide experience constipation
Only male mice were used in this study, and all experimental procedures were conducted in accordance with protocols approved by the Institutional Animal Care and Use Committee (Animal Ethics Approval: FDULAC20250381) and complied with Fudan University Laboratory Animal Center guidelines
On a systemic level, SCFAs regulate the UCP2-AMPK-ACC metabolic network via activation of peroxisome proliferator-activated receptor gamma (PPAR), which promotes fatty acid oxidation and mitigates ROS production induced by lipid accumulation [73]
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