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Heart rate effects peak around week 24 of treatment and then decline at weeks 36 and 48 even with continued dosing
Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
The Phase 1b trial was published in The Lancet in 2022, confirming the compound's half-life supported weekly administration
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