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Prevention of Neurological Damage : Vitamin B12 can be considered as essential in preserving nervous system integrity and preventing neurological damage by reversing deficiency

Certain medical conditions People with peripheral neuropathy in the legs may have reduced sensation that makes it difficult to judge injection depth and placement correctly

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Hypokalemia and thrombocytosis could occur upon conversion of severe megaloblastic anemia to normal erythropoiesis with methylcobalamin therapy