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Based on REDEFINE trial populations and the NDA submission terms, expected eligibility criteria are: BMI 30 , or BMI 27 with at least one weight-related condition such as hypertension, dyslipidemia, type 2 diabetes, or obstructive sleep apnea Adults 18 years or older Not pregnant or breastfeeding Contraindications will likely include: personal or family history of MTC or MEN 2 syndrome, prior serious allergic reaction to semaglutide or cagrilintide, and active pancreatitis
Problems may develop when ROS production remains excessive or antioxidant defenses are insufficient
Glutathione also plays a central role in the detoxification of drugs, pollutants, and other harmful substances
Cordeiro LMS, Rabelo PCR, Moraes MM, et al
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