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The alterations allow it to avoid binding to proteins in the body, allowing it to have a longer half-life
Gupta BL et al
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JAMA cardiology
In 5xFAD mice, selective neuronal loss is found in cortical layer 5 (L5), without affecting the overall neuron number in the total frontal cortex and hippocampus, and this correlates with the reduced anxiety-like behavior (Jawhar et al., 2012)
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