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Nuijten, M., Lnborg, J., & Levin, L

Likewise, administration of encapsulated bitter compounds derived from Gentiana lutea root with a standardized breakfast reduced total daily energy intake by ~20% in healthy individuals (60), while oral insensitivity to the bitter taste of 6-n-propylthrouracil was associated with increased energy intake in female subjects (72)

How the medication is taken also factors in

The direct and weight-independent actions of some new obesity pharmacotherapies in ectopic fat of specific organs may further enhance the potential for tailored treatment choices based on patients complications

Phase 3 adds a 6 mg step, creating a smoother escalation that reduces the size of each dose increase