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In cultured fibroblasts, this inhibition suggests regulatory control over cell migration and extracellular matrix remodeling [3]
A researcher running a 48-week protocol at 4mg weekly needs significantly less total material than one targeting 12mg maintenance
Current-use periods for a medication were defined as from the day after the index date to the end of presumed supply for consecutive dispensings plus a grace period of 30 days
longer-term protocols where sustained cortisol elevation would create welfare concerns in animal models
FDA (2025) 9
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