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However, Retatrutide is not yet Health Canada approved, with expected regulatory decisions coming in late 2026 or early 2027
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In the phase 2 clinical trial (Jastreboff et al., New England Journal of Medicine , 2023), retatrutide was administered as a once-weekly subcutaneous injection, with doses escalated gradually over time a regimen that reflects the trial protocol
In the STEP clinical trial program evaluating Wegovy for weight management, participants achieved mean weight reductions of 12% to 15% of baseline body weight over 68 weeks, significantly exceeding results seen with lifestyle modification alone
The rate of fading depends on individual skin cell turnover speed, exfoliation habits, and baseline melanin production
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