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After the matching, there were 1022 matched pairs of GLP-1RA and insulin users with no significant between-group difference in the baseline characteristics except for age, hyperlipidemia, and neuropathy (Additional file 1: Table S3)
These medicines augment glucose-dependent insulin secretion, inhibit glucagon release, and prolong gastric emptying
Insulin sensitivity improvements at 15 mg are substantial
Several studies lacked a proper concurrent placebo group
That is a net effect of approximately 2kg (4.4 pounds) over three months
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