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This study suggests that improvements in blood sugars and weight loss can potentially be sustained in the longer term for adults with type 2 diabetes taking semaglutide as prescribed Prof Karasik added: In this large real-world study, we were able to show durable reductions in HbA1c and body weight with emphasis on drug adherence

10.1016/j.expneurol.2014.08.026 159

This represents the highest weight loss ever recorded in a Phase 3 obesity trial, surpassing even the company's own dual agonist tirzepatide (Mounjaro/Zepbound), which achieved 22.5% in its pivotal studies

Those who let it slip lost muscle along with fat