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Tirzepatide (but not semaglutide) has been shown to have the following effects on oral contraception, which were not seen for semaglutide, or any of the less commonly used GLP-1 agonists

Here is what happened

Knowing these can help in taking proactive steps to reduce risk: Lifestyle Factors Smoking: Smoking damages blood vessels and can increase the tendency for blood to clot

The company is already seeking the FDAs approval of orforglipron, which could occur by early next year