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Two techniques are being used to measure endothelium-dependent vasodilation
More serious side effects include changes in cholesterol levels and abnormal liver enzymes
In addition to its effects on glucose metabolism, glucagon is suggested to induce body weight loss, by increasing satiety and enhancing hepatic lipid oxidation and whole-body energy expenditure (13)
The pattern of results, particularly the amplification of benefit at higher weight loss thresholds, is consistent with the hypothesis that HRT restores a metabolic environment that makes GLP-1 therapy more effective: improving insulin sensitivity, preserving lean mass, reducing the inflammatory burden that blunts metabolic responsiveness, and supporting the mitochondrial function that underlies energy regulation
Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]
