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The findings support the use of once-weekly subcutaneous semaglutide at a dose of 2.4 mg for weight management and treatment of pain in persons with obesity and moderate to severe pain due to knee osteoarthritis.

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The following represents a theoretical ultra-conservative approach based on monotherapy principles: Hypothetical Ultra-Conservative Schedule: This extended 24-week titration period doubles the typical monotherapy escalation timeline , reflecting the complete absence of interaction data and the overlapping side effect profiles