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GLP-1 users may differ from nonusers in ways that are not fully captured, such as socioeconomic status, health behaviors, disease severity, medication adherence, or access to care." Lakkis notes that the study also did not report how much weight participants lost, making it difficult to determine how much of the benefit may have been driven by weight reduction itself
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The combination of tirzepatide and metformin represents an evidence-based approach to managing type 2 diabetes mellitus, leveraging complementary mechanisms of action to optimize glycemic control
These results are significantly higher than those of participants who managed their weight with diet and exercise alone
