10.1080/2162402x.2021.1957605 180 ZhangZ.MaL.GoswamiS.MaJ.ZhengB.DuanM.et al (2019)
RGN-352 was shown to be safe and well-tolerated with no serious drug-related adverse events reported (PMID: 20536472) Phase 2 AMI trial (incomplete): RegeneRx designed a Phase 2 proof-of-concept trial (NCT01311518) to evaluate RGN-352 in approximately 75 patients with acute ST-segment elevation myocardial infarction (heart attack)

Epidemiology: High levels of vitamin B12 were found in: Causes: Excessive supplementation (a direct increase in plasma vitamin B12 by excess intake or administration) Increased release of vitamin B12 from tissue stores (liberation from an internal reservoir): Solid tumors (especially hepatic or hematologic malignancies) Liver metastases Increased binding proteins: 7 Excess production: Liver disease (e.g., hepatitis, cirrhosis, hepatocellular carcinoma) damaged hepatocytes release haptocorrin (transcobalamin I) and B12 into circulation Myeloproliferative disorders these increase granulocyte production, which leads to more haptocorrin (transcobalamin I/III), a B12-binding protein produced by proliferating myeloid cells
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