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This included treatment-emerging depression, exacerbation of depressive symptoms, fluctuations in depressive mood, and other clinically pertinent depressive-related events expressly covered in the studies.Considering the possible expanded effect of the GLP-1 RAs in mood and the central nervous system, the secondary outcomes were anxiety, mood disorder, suicidal thoughts, and mood-related adverse events.To increase the comparability and exhaustiveness of our analysis and investigate possible mediating variables about psychiatric adverse events, we also released data about metabolic parameters including body weight, BMI, fasting blood glucose, and lipid profiles

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Divide the dose 60/40 or 50/50 between morning (fasted) and evening (at least 2 hours after eating)