In the early pathological state of AD, glucose utilization (up to 45%) is reduced, which is closely related to the alteration of insulin signaling
Topical medications are the first-line therapy and include prostaglandin analogues, -blockers, -agonists, carbonic anhydrase inhibitors, and Rho-kinase inhibitors, each with distinct mechanisms and side-effect profiles [12,13,14]
A Well-Studied Compound The brand drug tirzepatide is FDA-approved as Mounjaro (for Type 2 diabetes) and Zepbound (for weight management)
10.1136/bmj.k1497 40 YangB.LiS.ChenZ.FengF.HeL.LiuB.et al (2020)
Even if only a fraction of those patients sought GLP-1 treatment, insurers could face billions of dollars in additional costs