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Across developmental, acute, and regional manipulations, elevated KYNA consistently reduces extracellular glutamate in both the hippocampus and prefrontal cortex [30, 74, 75, 81]

The median age of affected patients was 55, with 53% being female demographics that already face elevated gallbladder disease risk, making the failure to warn particularly egregious

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Therefore, we conclude that mitochondrial function is required to support this acute adaptive response to 5FU

Nelson, Biochemical Pharmacology, 2013 Glutathione depletion and oxidative stress in acetaminophen-induced liver injury , B