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High hepatic fat content is the important inducement of the impairment of redox imbalance and insulin resistance
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However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH

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FASEB J 34(1):945959
