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As such, no drugs in the GLP-1 agonists class are currently FDA-approved for treating or preventing cancer

Interestingly, despite the activation of caspases in late stages of parthanatos, caspase inhibitors cannot inhibit the parthanatos process except for blocking PARP1 activity, confirming that PARP1-mediated cell death is caspase-independent [137, 139]

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They lack evaluation of the mediators as chronic stress and intellectual level on the outcome

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