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Methionine and choline play vital roles in fat metabolism: they help the liver break down fats more efficiently and prevent accumulation of fat in the liver

Vitamin B12 plays essential roles in red blood cell formation, neurological function, and DNA synthesis

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Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c

Those have been years long, involving very large, extensive, rigorous, careful studies