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We sought to assess how such discontinuation affects weight gain and outcomes during pregnancy. For the study, the team analyzed electronic health records for 1,792 pregnancies delivered within the Mass General Brigham healthcare system between 20162025, primarily among women with obesity

2023 Mar 01;6(3):e236315

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Metformin (off-label for weight management) Metformin is the most widely prescribed diabetes medication in the world, and while it is not FDA-approved for weight loss, it consistently produces modest weight reduction of 2-5% in clinical studies

The total amount of hydrophobic amino acids, including L (7.98%), I (3.13%) and V (2.85%), is relatively high, which may be related to the fact that they can form a hydrophobic core with tyrosinase or combine with hydrophobic pockets of tyrosinase