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His work however came to a halt with the outbreak of the First World War which required him to serve as a military doctor and forced Hoffman-La-Roche to close down its Acomatol production plant (Hall
Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, et al
11 , eaau8587 (2019)
Outside of the context of deficiency, this phenomenon is presumed to occur through inhibition of another enzyme called pyruvate dehydrogenase kinase which essentially removes the block from the PDH complex
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