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Private insurance plans increasingly cover these medications for approved indications, though often with requirements like prior authorization, step therapy, or documented failed attempts at lifestyle modification

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Prior to the initiation of valproic acid therapy, evaluation for UCD should be considered in the following patients: 1) those with a history of unexplained encephalopathy or coma, encephalopathy associated with a protein load, pregnancy-related or postpartum encephalopathy, unexplained mental retardation, or history of elevated plasma ammonia or glutamine

Hydrogen sulfide-mediated vasodilatory activity The preservation of normal arterial function plays an important role in cardiovascular disease prevention

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