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It would be important to reassess this pattern now with more widespread adoption of GLP-1s for obesity alone, since the study period ended in 2022

Furthermore, the study did not measure the levels of quinolinic acid (QUIN) or kynurenic acid (KA), which would offer a more detailed understanding of the balance in TRP metabolism (neurotoxic versus neuroprotective pathways) and the involvement of TRP metabolites in the pathophysiology of depressive disorder

Tenofovir is not recommended for patients with renal or kidney dysfunction

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