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QNP showed superior efficacy to free quercetin, improving autism-like behaviors, restoring antioxidant enzyme activity, and modulating apoptotic and antioxidant gene expression (Moghaddam et al., 2023)

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With advancing age, cortisol secretion increases, circadian rhythmicity flattens, and glucocorticoid receptormediated negative feedback becomes impaired due to hypothalamic and pituitary dysfunction (Ferrari et al

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