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they increase insulin and decrease glucagon secretion in a glucose-dependent manner, decrease appetite and increase satiety) and thereby lower glucose levels, while avoiding hypoglycaemia, and produce weight loss

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Although thiamine deficiency is rare in developed countries, it can lead to severe neurological disorders, emphasizing the importance of adequate thiamine intake for optimal health and as treatment when administered promptly (, )

Its the first non-peptide GLP-1 agonist to receive FDA approval, after trials showed its safety and efficacy are similar to other GLP-1s approved for chronic weight management in adults with obesity