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Epithalon peptide experimentation appeared to have led to an upregulation of neurogenic differentiation markers, including Nestin, GAP43, Tubulin III, and Doublecortin, in hGMSCs

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This present study not only revealed the expression changes of vasoactive intestinal peptide [and its] receptors within human nucleus pulposus tissue, but also demonstrated [its] protective effects [against] degeneration, said Jingchuan Sun, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study