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This age-related decline correlates with many hallmarks of aging, including reduced collagen production, slower wound healing, increased inflammation, and diminished tissue repair capacity
Transcriptome analysis of pathway enrichment (Supplemental Figure 6A) and gene set enrichment analysis (GSEA) Supplemental Figure 6B) indicated that the hallmark pathway of glutamine family amino acid metabolic process was among the top-ranking upregulated gene sets in A2ARi-treated cells
B12 supplementation deserves special mention
The mechanism is not well established it may relate to individual sensitivity, dehydration coinciding with supplement use, or other unrelated factors
