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The results showed that all studies had total scores between 2 and 3 (out of a maximum of 10), indicating low overall methodological quality

Abstract Background lipedema is a chronic, progressive adipose disorder predominantly affecting women, characterized by painful, symmetrical subcutaneous fat accumulation, and typically resistant to lifestyle interventions

33 KariusT.SchnekenburgerM.GhelfiJ.WalterJ.DicatoM.DiederichM

This immunometabolic reprogramming is governed by signaling pathways (mTOR, AMPK, HIF-1) that respond to acute environmental cues rather than genetic transformation, and rapidly reverts to oxidative phosphorylation upon stimulus withdrawal (56, 57)

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