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Each injection should contain at least 5,000 mcg of pharmaceutical-grade methylcobalamin to be effective, and most patients notice improvements in energy, sleep, and mood within weeks of starting proper B12 therapy

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Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12

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Some users find that taking their injection on a day when they can rest (like a Friday evening) helps them manage the first 2448 hours of side effects more comfortably