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10.1021/bi990852f 45
Crucially, they trigger insulin release only when glucose is already present in the bloodstream, minimizing the risk of dangerous hypoglycemia seen with some older diabetes drugs
This approach, which often involves applying a fraction of the standard dose, is designed to investigate the cellular or physiological responses without provoking the full-blown effects of the drug
However, there is limited experience in patients with severe renal impairment or end-stage renal disease, so caution is advised
Supports against oxidative stress
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