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The boundary between type I and type II cell death is not entirely clear
Retrograde Mitochondrial-Nuclear Signaling One interesting feature of MOTS-c biology is that MOTS-c seems to travel to the nucleus of cells under conditions of stress and alter the expression of nuclear genes that control antioxidant defences as well as metabolic programs
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Iorio A et al
Thus, the ISR is more sensitive to cysteine insufficiency in comparison to GSH depletion
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