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Your prescribing clinician at PlexusDx will review your baseline kidney function, electrolytes, and GI tolerance before recommending whether to continue, adjust, or discontinue metformin alongside your compounded GLP-1 protocol
That doesnt mean it hasnt happened, I have just not observed it
The key point: the best option depends on the reason for low B12 and your clinical context
doi: 10.1016/j.ijpddr.2024.100549 24
The SURMOUNT-5 clinical trial published in The New England Journal of Medicine showed that Zepbound (tirzepatide) achieved an average weight loss of 20.2% compared to 13.7% with Wegovy (semaglutide) at 72 weeks
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