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Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) have a boxed warning contraindication for semaglutide and tirzepatide, based on thyroid C-cell tumor findings in rodents [17]
Clinical Gastroenterology and Hepatology, Volume 22, Issue 6, 1255 - 1264.e18
Other GLP-1R populations in the ACB, LSc, PVH, lateral hypothalamus (LHA), and VTA are involved in food choice, reward, and taste aversion (2125)
