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You should contact your GP if you experience: Absence of periods for three consecutive cycles (amenorrhoea) if you previously had regular menstruation Unusually heavy bleeding (soaking through a pad or tampon every hour for several consecutive hours) or passing large clots Bleeding between periods or after intercourse, which requires investigation regardless of medication use Severe pelvic pain that differs from typical menstrual cramping Symptoms of anaemia including persistent fatigue, breathlessness, palpitations, or pallor Seek urgent medical help via NHS 111 or A&E for very heavy bleeding with dizziness or fainting, or severe abdominal pain that could indicate complications such as pancreatitis

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HEP regulates iron levels by binding to ferroportin (FPN), and the FPN/hepcidin regulatory axis that allows precise control of iron at both systemic as well as cellular levels 487

Melanotic neuroectodermal tumour of infancy presenting as an undifferentiated round cell tumour in the soft tissue of the forearm

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