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doi: 10.1016/j.mayocpiqo.2019.08.005 67
Association between different GLP-1 receptor agonists and Gastrointestinal adverse reactions: A real-world disproportionality study based on FDA adverse event reporting system database
Soukhathammavong P, Odermatt P, Sayasone S, Vonghachack Y, Vounatsou P, Hatz C, Akkhavong K, Keiser J
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In addition to different signal strength, the distinct conformation of c-MET triggered by different types of ligand may allow it to preferentially activate different downstream signaling pathways through engaging distinct sets of downstream effectors, which is reminiscent of the biased agonism paradigm established for other RTKs, such as EGFR 35
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