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This review synthesizes progress in Tirzepatide research to educate clinicians and the general public about the benefits and pathophysiological underpinnings of the drug

The effect of TZDs on kidney function has been previously described in mice models (Sarafidis et al., 2010) and in a large study involving 4351 diabetic patients ( Another interesting class of hypoglycemic drugs with positive kidney outcomes are the SGLT2 inhibitors (SGLT2i) which inhibit glucose and sodium reabsorption in the PT (Williams et al., 2020)

Adverse effects such as tachycardia, infections, headaches, dizziness, nausea, vomiting, diarrhea, and dyspepsia, as well as contraindications such as a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, hypersensitivity, severe gastrointestinal diseases, renal impairment, and pregnancy have been noted

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