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Bezchlebov, J., Cernohlvkov, J., Kobeticov, K., Lna, J., Sochov, I., & Hofman, J

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Radiation induced intestinal injury model: promoting mucosal repair and maintaining barrier integrity Radiation induced intestinal injury is a common complication of abdominal tumor radiotherapy, mainly manifested as intestinal mucosal damage and barrier dysfunction

The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting