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Across 2,783 participants, GLP-1RAs were associated with: - Higher rates of MASH resolution without worsening fibrosis - Reduced liver fat and improved ALT, AST, and GGT levels - Significant decreases in body weight, BMI, waist circumference, HbA1c, and triglycerides While gastrointestinal side effects (nausea, vomiting, diarrhea) were more common, the overall benefit profile was substantial
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Tirzepatide is not currently authorized by Health Canada for obstructive sleep apnea, despite a 2024 US FDA approval for that indication
Recently, the GLIMPLES Italian multicenter retrospective study investigated the effectiveness on HbA1c levels and body weight of oral semaglutide in 166 patients with T2D who initiated the medication and were followed for 18 months
[31] Blood glucose monitoring may need to be intensified when initiating lisinopril in diabetic patients
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