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Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA

Wjcik P, Ggotek A, arkovi N, Skrzydlewska E

[5] [6] However, retatrutide remains an investigational compound and has not been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for any clinical use

Serious eye complications are unrelated to the medication itself and require immediate medical evaluation

Kvitne KE, Robertsen I, Skovlund E, et al