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In large clinical trials such as TRIUMPH-4, these agents have demonstrated substantial weight loss and improvements in inflammatory and cardiometabolic markers [33]

In summary, development defects in the CNS in GDH-HI patients could be caused by multiple factors, including chronic hyperammonemia, and hyperinsulinemia, the more detailed mechanisms need to be further studied

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Long used in Indian and Chinese traditional medicine, berberine is described by Apollo Hospitals as a naturally occurring alkaloid associated with anti-microbial, anti-inflammatory and metabolic regulatory properties