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A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class

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PK and PD analysis The PK of AMG 133 was evaluated using a validated liquid-chromatography tandem mass spectrometry (LCMS/MS) methodology to detect total AMG 133, defined as the GIPR-Ab with or without the GLP-1 analogue peptides and intact AMG 133, defined as the GIPR-Ab with at least one attached GLP-1 analogue peptide

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