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Can weight loss help kidney transplant eligibility
Each receptor contributes a different piece: GLP-1 reduces appetite and slows digestion GIP improves insulin sensitivity and fat metabolism Glucagon increases energy expenditure and fat breakdown The result is up to 24% average weight loss in Phase 2 trials, with Phase 3 data showing even higher numbers (28.7% at 68 weeks)
SOURCE HUM Nutrition
This is due to the medications dual action: it mimics the GLP-1 hormone to signal fullness to the brain while simultaneously slowing down gastric emptying
Together these data indicate that although vagal afferent neurons may contribute to hypophagia induced by peripheral administration of GLP-1R analogs, these neurons are not necessary for the hypophagic effect
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