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Since obesity is a chronic illness that can lead to type 2 diabetes, cardiovascular disease, certain cancers, and sleep disorders, the FDA responded by approving the use of semaglutide in increased dosages for treating obesity and overweight individuals with certain weight-related diseases

The FDA also said that some compounding pharmacies claiming to sell semaglutide might instead be selling other formulations of the chemical, like semaglutide sodium and semaglutide acetate

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The broad, shortage-based compounding pathway ended after the FDA resolved the semaglutide and tirzepatide shortages, and in April 2026 the FDA proposed excluding these drugs from the 503B outsourcing-facility bulks list, with a comment period through June 29, 2026