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Interestingly, resistance training appears to increase IGF-1 activity, at least in middle aged women

5,288,289 Oxidative Stress Free radicals, especially oxidized low-density lipoprotein (LDL), promote vascular inflammation, increase the expression of tissue factor on cellular surfaces, damage proteins that regulate coagulation, heighten reactivity of platelets, and disrupt antithrombotic hemostatic mechanisms, raising the risk of thrombosis

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Given that blood pressure drops dramatically following resistance exercise, an increase in pulsatility, a drop in resistance, and an overall increase in MCAv (and likely cerebral perfusion) are indicative of an emergency protective response to avoid pre-syncope and syncope (Koch et al., 2005)

In senescent cells, FOXO4 binds to p53 and prevents apoptosis, allowing these damaged cells to persist