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However, GSSG supplementation did no longer lead to reduction of Grx1-roGFP2 in these strains, independent on whether the periplasmic binding protein GsiB or the permease domains GsiC or GsiD were missing, suggesting that Gsi is the exclusive transporter for oxidized glutathione in E

Rather, mutations affecting the dimerization interfaces of the G6PD protein and in proximity to the NADP + binding site may cause more detrimental effects compared to mutations of residues in other less conserved sites

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Both share GI-dominant side effects, and head-to-head data showed broadly comparable tolerability

Because they are smaller and simpler than full proteins, your body can absorb and utilize them efficiently